Antistreptokinase antibodies: implications for thrombolysis in a region with endemic streptococcal infection.

نویسندگان

  • N Blackwell
  • A Hollins
  • G Gilmore
  • R Norton
چکیده

AIMS To determine antistreptokinase antibody (anti-SK) titres in patients with the acute coronary syndrome from communities with endemic group A streptococcal infection because of the implications for streptokinase (SK) thrombolysis. METHODS Anti-SK titres were determined using a standard method in 47 consecutive SK naive patients, presenting to the Mt Isa Hospital emergency department, Australia, with an acute coronary syndrome. Both indigenous and non-indigenous subjects were enrolled. Antistreptolysin O (ASOT) and anti-DNAse B (ADB) titres were also determined. RESULTS Indigenous patients were more likely to have anti-SK antibodies (p < 0.001) than the non-indigenous cohort. Anti-SK antibody titres also correlated well with ASOT/ADB titres. CONCLUSIONS Anti-SK antibodies are highly prevalent in SK naive indigenous patients presenting with the acute coronary syndrome. Streptokinase should not be used for thrombolysis in populations with endemic group A streptococcal infection.

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عنوان ژورنال:
  • Journal of clinical pathology

دوره 58 9  شماره 

صفحات  -

تاریخ انتشار 2005